SCHEMBL9218902

SCHEMBL9218902

Cc1cccc2c1C(=O)N(C(C)NC(C)N1C(=O)c3cccc(C)c3C1=O)C2=O

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.44
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
TYMS P04818 4/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
DDB1 Q16531 1/20 0.39
CRBN Q96SW2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12420865 0.84 DPP4 (0.47) DPP4PDE4APDE4BPDE4CPDE4D
SCHEMBL6577160 0.80 TDP1 (0.52) ALDH1A1HPGD
SCHEMBL11037137 0.77 TDP1 (0.49) ALDH1A1HPGD
SCHEMBL4466937 0.71 DPP4 (0.45) DPP4TYMSALDH1A1DDB1CRBN
SCHEMBL24421365 0.71 DPP4 (0.51) DPP4TYMSALDH1A1DDB1CRBN
SCHEMBL13239551 0.71 MEN1 (0.54) DPP4TYMSALDH1A1HPGDDDB1
SCHEMBL5326245 0.70 DPP4 (0.51) DPP4PDE4APDE4BPDE4CPDE4D
SCHEMBL31259865 0.70 DPP4 (0.51) DPP4PDE4APDE4BPDE4CPDE4D
SCHEMBL6255737 0.70 POLB (0.50) TYMSALDH1A1HPGD
SCHEMBL21946651 0.70 GAA (0.38) DPP4PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995000576-A1 NOVEL PHTHALIMIDES AND REVERSIBLY CROSSLINKED IMIDE POLYMERS AKZO NOBEL N.V. (NL) 1995-01-05 WO disclosed