SCHEMBL9221503

SCHEMBL9221503

CCCCC[C@H]1CC[C@H](COc2ccc(F)c(F)c2)CC1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 3/20 0.44
PARP15 Q460N3 2/20 0.44
TDP1 Q9NUW8 1/20 0.43
SCN9A Q15858 2/20 0.42
FFAR4 Q5NUL3 1/20 0.40
PDK2 Q15119 1/20 0.39
FFAR1 O14842 2/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
HTR3A P46098 1/20 0.37
KCNH2 Q12809 1/20 0.37
KDR P35968 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9221511 1.00 PARP10 (0.44) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9225857 0.96 PARP10 (0.41) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9225852 0.96 PARP10 (0.41) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9221785 0.96 PARP10 (0.45) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9221776 0.96 PARP10 (0.45) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9223448 0.92 PARP10 (0.42) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9223451 0.92 PARP10 (0.42) PARP10PARP15TDP1SCN9AFFAR4
SCHEMBL9188856 0.90 TDP1 (0.44) TDP1PDK2
SCHEMBL9188863 0.90 TDP1 (0.44) TDP1PDK2
SCHEMBL9227647 0.90 PARP10 (0.47) PARP10PARP15TDP1SCN9AFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995009827-A1 3,4-DIFLUOROBENZENES AND THEIR USE IN LIQUID-CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 1995-04-13 WO disclosed