Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 18/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 14/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910392 | 0.89 | PIK3CD (0.86) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL478238 | 0.83 | PIK3CA (0.60) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL2811275 | 0.81 | PIK3R1 (1.00) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL909510 | 0.81 | PIK3CD (0.83) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL909088 | 0.81 | PIK3CD (0.83) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL477471 | 0.80 | PIK3CD (0.81) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL908624 | 0.80 | PIK3CD (0.83) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL12790101 | 0.80 | PIK3CD (0.71) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL477981 | 0.79 | PIK3CA (0.87) | PIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL909577 | 0.77 | PIK3CA (0.88) | PIK3CDPIK3R1PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | claimed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | claimed |
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |