Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9225311 | 1.00 | KCNH2 (0.50) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9224452 | 0.86 | KCNH2 (0.60) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9224440 | 0.86 | KCNH2 (0.60) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226352 | 0.86 | KCNH2 (0.60) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226364 | 0.86 | KCNH2 (0.60) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9624200 | 0.78 | KCNH2 (0.57) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9626240 | 0.78 | KCNH2 (0.55) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226517 | 0.77 | KCNH2 (0.46) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226525 | 0.77 | KCNH2 (0.46) | KCNH2CACNA1FCHRM2ADRA2BADRA2C | |
| SCHEMBL9226308 | 0.76 | KCNH2 (0.79) | KCNH2CACNA1FCHRM2ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | claimed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | claimed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | claimed |
| US-5405997-A | Stable against rapid metabolism | THE UPJOHN COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| EP-0484378-B1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | UPJOHN CO (US) | 1994-09-14 | — | — | EP | disclosed |
| EP-0484378-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES. | UPJOHN CO (US) | 1992-05-13 | — | — | EP | disclosed |
| WO-1991001299-A1 | ANTIARRHYTHMIC TERTIARY AMINE-ALKENYL-PHENYL-ALKANESULFONAMIDES | THE UPJOHN COMPANY (US) | 1991-02-07 | — | — | WO | disclosed |