SCHEMBL9229487

SCHEMBL9229487

O=c1c2ccccc2c(-c2ccc(F)cc2)nn1-c1ccc(Cl)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 7/20 0.80
GAA P10253 4/20 0.80
KDM4E B2RXH2 2/20 0.73
ALDH1A1 P00352 3/20 0.59
CYP1A2 P05177 2/20 0.59
CYP2D6 P10635 2/20 0.59
CYP2C9 P11712 2/20 0.59
CYP2C19 P33261 2/20 0.59
HTT P42858 2/20 0.59
NPC1 O15118 2/20 0.58
RAB9A P51151 2/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
ALOX5 P09917 1/20 0.55
LMNA P02545 5/20 0.53
SRC P12931 1/20 0.50
BRAF P15056 1/20 0.50
KDR P35968 1/20 0.50
CYP3A4 P08684 1/20 0.50
PDE4A P27815 1/20 0.49
PDE4B Q07343 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9225993 0.93 NPSR1 (0.82) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL9230974 0.88 NPSR1 (0.61) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL9229776 0.85 NPSR1 (0.58) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL9171902 0.84 NPSR1 (0.56) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL9279562 0.81 NPSR1 (0.72) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL22721559 0.80 NPSR1 (0.56) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL29539384 0.80 NPSR1 (0.56) NPSR1GAAKDM4EALDH1A1CYP1A2
Water SCHEMBL22721771 0.79 NPSR1 (0.63) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL22721773 0.79 NPSR1 (0.63) NPSR1GAAKDM4EALDH1A1CYP1A2
SCHEMBL22721748 0.79 MEN1 (0.68) NPSR1GAAKDM4EALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634404-A1 Phtalazin derivatives and their use as pesticides RHONE POULENC AGRICULTURE LTD. (GB) 1995-01-18 EP claimed
EP-0634404-A1 Phtalazin derivatives and their use as pesticides RHONE POULENC AGRICULTURE LTD. (GB) 1995-01-18 EP disclosed