Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.33 |
| ▸ | STAT3 | P40763 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132889 | 1.00 | TOP2A (0.33) | TOP2ATOP2BSTAT3ALDH1A1POLB | |
| SCHEMBL8322655 | 0.94 | TOP2A (0.33) | TOP2ATOP2BSTAT3KDM4ECYP3A4 | |
| SCHEMBL7524708 | 0.87 | TOP2A (0.44) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL9047223 | 0.87 | TOP2A (0.38) | TOP2ATOP2BSTAT3ALDH1A1POLB | |
| SCHEMBL9236365 | 0.87 | TOP2A (0.38) | TOP2ATOP2BSTAT3ALDH1A1POLB | |
| SCHEMBL7607385 | 0.87 | TOP2A (0.38) | TOP2ATOP2BSTAT3ALDH1A1POLB | |
| SCHEMBL8337308 | 0.86 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL9096255 | 0.86 | TOP2A (0.45) | TOP2ATOP2BALDH1A1POLBCHRM2 | |
| SCHEMBL8133058 | 0.84 | TOP2A (0.37) | TOP2ATOP2BSTAT3ALDH1A1POLB | |
| SCHEMBL8138663 | 0.84 | TOP2A (0.34) | TOP2ATOP2BALDH1A1POLBCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653425-A1 | 1-(2-Fluorocyclopropyl)-quinolone- and naphthyridone carboxylic acid derivatives, their preparation and their use as antibacterials | BAYER AG (DE) | 1995-05-17 | — | — | EP | disclosed |