Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL21879667 | 1.00 | TDP1 (0.52) | TDP1ATML3MBTL1ALOX15HPGD | |
| Bicarbonate SCHEMBL1393750 | 1.00 | TDP1 (0.52) | TDP1ATML3MBTL1ALOX15HPGD | |
| Bicarbonate SCHEMBL9332184 | 1.00 | TDP1 (0.52) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL18073 | 0.97 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL9353461 | 0.97 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL27352197 | 0.97 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL9353455 | 0.97 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL9241160 | 0.97 | TDP1 (0.54) | TDP1ATML3MBTL1ALOX15HPGD | |
| Bicarbonate SCHEMBL28174005 | 0.95 | TDP1 (0.48) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL1362173 | 0.94 | TDP1 (0.52) | TDP1ATML3MBTL1ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391690-A | Reacting aromatic dihydroxyl compound with diester of carbonic acid and/or diester of dicarboxylic acid in presence of transesterification catalyst and organic phosphorus compound or mixture of phosphorus compound and hindered phenol | DAICEL CHEMICAL INDUSTRIES,LTD. (JP) | 1995-02-21 | — | — | US | disclosed |
| US-5387628-A | Transesterification catalyst; polymerization in presence of organic phosphorus compound and a hindered phenol | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-07 | — | — | US | disclosed |