SCHEMBL924410

SCHEMBL924410

COC(=O)CCc1cc(N)c(OC2Cc3ccccc3C2)c(-c2ccc3c(cnn3C)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.42
CCNC P24863 5/20 0.37
CDK8 P49336 5/20 0.37
TRPA1 O75762 1/20 0.37
PDE1C Q14123 3/20 0.36
FAAH O00519 1/20 0.36
CREBBP Q92793 2/20 0.36
USP7 Q93009 1/20 0.35
BRD4 O60885 1/20 0.35
POLQ O75417 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ak-106 SCHEMBL924434 0.92 AR (0.43) ARCCNCCDK8TRPA1PDE1C
Ak-106 SCHEMBL29359236 0.92 AR (0.43) ARCCNCCDK8TRPA1PDE1C
SCHEMBL3883868 0.90 CCNC (0.36) ARCCNCCDK8
SCHEMBL3686310 0.89 AR (0.40) ARCCNCCDK8PDE1CFAAH
SCHEMBL924546 0.87 AR (0.38) ARCCNCCDK8TRPA1PDE1C
SCHEMBL3891649 0.87 PTPN1 (0.36) ARCCNCCDK8FAAHCREBBP
SCHEMBL3884507 0.87 AR (0.41) ARCCNCCDK8TRPA1CREBBP
SCHEMBL3888617 0.85 CCNC (0.47) CCNCCDK8
SCHEMBL923456 0.85 AR (0.38) ARCCNCCDK8PDE1CCREBBP
SCHEMBL925771 0.84 AR (0.39) ARCCNCCDK8TRPA1PDE1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2620431-A1 Novel crystals of substituted phenylalkanoic acid and production process Asahi Kasei Pharma Corporation (JP) 2013-07-31 EP claimed
US-7838546-B2 Crystal of substituted phenylalkanoic acid ester and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2010-11-23 US claimed
US-20100234440-A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID ESTER AND PROCESS FOR PRODUCING THE SAME SHODA MOTOSHI 2010-09-16 US claimed
EP-2045244-A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS Asahi Kasei Pharma Corporation (JP) 2009-04-08 EP claimed
US-20080070967-A1 Novel crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2008-03-20 US claimed
US-9006225-B2 Stable pharmaceutical composition ASAHI KASEI PHARMA CORPORATION (JP) 2015-04-14 US disclosed
CN-102690234-B Novel crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORP 2014-12-24 CN disclosed
EP-2620431-A1 Novel crystals of substituted phenylalkanoic acid and production process Asahi Kasei Pharma Corporation (JP) 2013-07-31 EP disclosed
CN-102690234-A Novel crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORP 2012-09-26 CN disclosed
CN-101490012-B Novel crystal of substituted phenylalkanoic acid and process for producing same ASAHI KASEI PHARMA CORP 2012-07-18 CN disclosed
US-7935720-B2 Crystal of substituted phenylalkanoic acid ester and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2011-05-03 US disclosed
US-7935720-B2 Crystal of substituted phenylalkanoic acid ester and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2011-05-03 US disclosed
CN-101490012-A Novel crystal of substituted phenylalkanoic acid and process for producing same ASAHI KASEI PHARMA CORP (JP) 2009-07-22 CN disclosed
US-7560478-B2 Crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2009-07-14 US disclosed
US-7560478-B2 Crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2009-07-14 US disclosed
EP-2045244-A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS Asahi Kasei Pharma Corporation (JP) 2009-04-08 EP disclosed
EP-2045244-A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS Asahi Kasei Pharma Corporation (JP) 2009-04-08 EP disclosed
US-20080070967-A1 Novel crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2008-03-20 US disclosed
US-20080070967-A1 Novel crystal forms of substituted phenylalkanoic acids and process for producing the same ASAHI KASEI PHARMA CORPORATION (JP) 2008-03-20 US disclosed
WO-2008010448-A1 NOVEL CRYSTAL OF SUBSTITUTED PHENYLALKANOIC ACID AND PRODUCTION PROCESS ASAHI KASEI PHARMA CORPORATION (JP) 2008-01-24 WO disclosed