SCHEMBL9246705

SCHEMBL9246705

CCC[C@H]1CO[C@H](C#Cc2cnc(-c3ccc(F)c(F)c3)nc2)OC1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 1/20 0.31
GRM2 Q14416 1/20 0.30
OPRL1 P41146 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2B Q13224 1/20 0.30
KDM1A O60341 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9246715 1.00 NPY5R (0.31) NPY5RGRM2OPRL1GRIN1GRIN2B
SCHEMBL9243084 0.94 NPC1 (0.33) NPY5R
SCHEMBL9243088 0.94 NPC1 (0.33) NPY5R
SCHEMBL9246002 0.93 PDE5A (0.33)
SCHEMBL9246012 0.93 PDE5A (0.33)
SCHEMBL9247654 0.91 RPS6KB1 (0.31)
SCHEMBL9247648 0.91 RPS6KB1 (0.31)
SCHEMBL9245085 0.88 GRM5 (0.32)
SCHEMBL9245076 0.88 GRM5 (0.32)
SCHEMBL9241228 0.87 GRM2 (0.38) GRM2KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5447657-A Liquid crystal compounds HOFFMANN-LA ROCHE INC. (US) 1995-09-05 US disclosed