Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
| ▸ | LCK | P06239 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | PTPRC | P08575 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL31442655 | 0.82 | SLC7A5 (0.87) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| Levodopa SCHEMBL9108304 | 0.82 | SLC7A5 (0.87) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| SCHEMBL1248325 | 0.82 | SLC7A5 (0.71) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| Levodopa SCHEMBL17685886 | 0.82 | SLC7A5 (0.87) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| Levodopa SCHEMBL13719874 | 0.82 | SLC7A5 (0.87) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| SCHEMBL5321753 | 0.82 | SLC7A5 (0.71) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| SCHEMBL29585153 | 0.82 | SLC7A5 (0.71) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| SCHEMBL20912657 | 0.82 | SLC7A5 (0.71) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| SCHEMBL20912658 | 0.82 | SLC7A5 (0.71) | SLC7A5ALOX15HSD17B10TDP1KDM4E | |
| Levodopa SCHEMBL29653523 | 0.82 | SLC7A5 (0.87) | SLC7A5ALOX15HSD17B10TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418375-B1 | PHOSPHORYLATED DERIVATIVES OF L-DOPA AND COMPOSITIONS | PAWELEK JOHN M (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5100654-A | Treatment of pigmentation disorders, suntan lotion | YALE UNIVERSITY (US) | 1992-03-31 | — | — | US | disclosed |
| EP-0418375-A4 | PHOSPHORYLATED DERIVATIVES OF L-DOPA AND COMPOSITIONS AND METHODS FOR INCREASING THE MELANIN CONTENT IN MAMMALIAN SKIN HAIR | — | 1991-09-11 | — | — | EP | disclosed |
| EP-0418375-A1 | PHOSPHORYLATED DERIVATIVES OF L-DOPA AND COMPOSITIONS AND METHODS FOR INCREASING THE MELANIN CONTENT IN MAMMALIAN SKIN HAIR. | PAWELEK JOHN M (US) | 1991-03-27 | — | — | EP | disclosed |
| WO-1990012016-A1 | PHOSPHORYLATED DERIVATIVES OF L-DOPA AND COMPOSITIONS AND METHODS FOR INCREASING THE MELANIN CONTENT IN MAMMALIAN SKIN HAIR | PAWELEK JOHN M (US) | 1990-10-18 | — | — | WO | disclosed |