SCHEMBL9249382

SCHEMBL9249382

C=CCCCC1CCC(C2CCC(CCc3ccc(F)c(F)c3)CC2)CC1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
NPC1 O15118 1/20 0.33
CNR1 P21554 1/20 0.32
MAOB P27338 3/20 0.31
MAOA P21397 2/20 0.31
ALDH1A1 P00352 1/20 0.31
HTT P42858 1/20 0.31
CHRM5 P08912 1/20 0.30
CHRM1 P11229 1/20 0.30
CHRM3 P20309 1/20 0.30
TBXA2R P21731 1/20 0.30
PTGER4 P35408 1/20 0.30
PTGER3 P43115 1/20 0.30
PTGER2 P43116 1/20 0.30
DAO P14920 1/20 0.30
ACHE P22303 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9249390 1.00 SLC6A2 (0.33) SLC6A2SLC6A4SLC6A3NPC1CNR1
SCHEMBL9249372 1.00 SLC6A2 (0.33) SLC6A2SLC6A4SLC6A3NPC1CNR1
SCHEMBL9256842 0.92 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3NPC1CNR1
SCHEMBL9256823 0.92 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3NPC1CNR1
SCHEMBL9256837 0.92 SLC6A2 (0.35) SLC6A2SLC6A4SLC6A3NPC1CNR1
SCHEMBL9248469 0.89 DAO (0.32) SLC6A2SLC6A4SLC6A3MAOBDAO
SCHEMBL9248455 0.89 DAO (0.32) SLC6A2SLC6A4SLC6A3MAOBDAO
SCHEMBL9248476 0.89 DAO (0.32) SLC6A2SLC6A4SLC6A3MAOBDAO
SCHEMBL9253001 0.89 PROKR1 (0.33)
SCHEMBL9253009 0.89 PROKR1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5454974-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1995-10-03 US disclosed
US-5302317-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
EP-0315014-B1 Halogenated benzene derivatives HOFFMANN LA ROCHE (CH) 1994-01-12 EP disclosed
EP-0315050-B1 ALCENYL BICYCLOHEXANES F. HOFFMANN-LA ROCHE AG (CH) 1993-09-01 EP disclosed
US-5230826-A HALOBENZENE LIQUID CRYSTALS HOFFMANN-LA ROCHE INC. (US) 1993-07-27 US disclosed
US-5013477-A Alkenylbicyclohexane liquid crystals HOFFMANN-LA ROCHE INC. (US) 1991-05-07 US disclosed
EP-0331933-A2 Liquid crystal mixture with a low optical anisotropy F. HOFFMANN-LA ROCHE AG (CH) 1989-09-13 EP disclosed
EP-0315050-A2 Alcenyl bicyclohexanes F. HOFFMANN-LA ROCHE AG (CH) 1989-05-10 EP disclosed