Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCR9 | P51686 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252947 | 0.84 | POLB (0.36) | POLBGAANPSR1CCR9MAPT | |
| SCHEMBL14564431 | 0.75 | KDM4E (0.49) | POLBMAPTLMNAKDM4ETP53 | |
| SCHEMBL14564395 | 0.74 | MAPT (0.51) | POLBNPSR1MAPTLMNAMEN1 | |
| SCHEMBL9310207 | 0.74 | BTK (0.52) | POLBGAAMAPTLMNAKMT2A | |
| SCHEMBL28104161 | 0.72 | GAA (0.41) | POLBGAANPSR1MAPTKMT2A | |
| SCHEMBL17979387 | 0.71 | MAPT (0.45) | POLBMAPTKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL637196 | 0.71 | NPC1 (0.42) | POLBMAPTLMNAKMT2AKDM4E | |
| SCHEMBL9245910 | 0.71 | POLB (0.45) | POLBGAANPSR1MAPTLMNA | |
| SCHEMBL2796642 | 0.70 | MAPT (0.40) | POLBMAPTLMNAKDM4ETP53 | |
| SCHEMBL2795454 | 0.69 | TP53 (0.39) | POLBMAPTLMNAKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |