Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 18/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 18/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 17/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 16/20 | 1.00 |
| ▸ | AKT1 | P31749 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL926036 | 0.95 | PIK3CB (0.90) | PIK3CBPIK3CDPIK3CAPIK3CGAKT1 | |
| SCHEMBL926769 | 0.91 | PIK3CD (0.84) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL17881171 | 0.91 | PIK3CD (0.83) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL926394 | 0.91 | PIK3CB (0.83) | PIK3CBPIK3CDPIK3CAPIK3CGAKT1 | |
| SCHEMBL17881201 | 0.90 | PIK3CD (0.85) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL17881167 | 0.89 | PIK3CD (0.85) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL17881157 | 0.89 | PIK3CD (1.00) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL17881190 | 0.89 | PIK3CD (0.80) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL927233 | 0.89 | PIK3CB (0.79) | PIK3CBPIK3CDPIK3CAPIK3CGAKT1 | |
| SCHEMBL927897 | 0.88 | PIK3CB (0.79) | PIK3CBPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | claimed |
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | claimed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | claimed |
| WO-2016101553-A1 | NEW PI3K KINASE INHIBITOR | 中国科学院合肥物质科学研究院 | 2016-06-30 | — | — | WO | disclosed |
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |
| EP-1841763-B1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | ASTRAZENECA AB (SE) | 2010-06-30 | — | — | EP | disclosed |
| CN-101484452-A | Thiazole derivatives and their use as anti-tumour agents | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
| EP-2016075-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | AstraZeneca AB (SE) | 2009-01-21 | — | — | EP | disclosed |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | ASTRAZENECA AB (SE) | 2008-06-05 | — | — | US | disclosed |
| WO-2007129044-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |
| EP-1841763-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | AstraZeneca AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006051270-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076009-A1 | THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS | MTOR, RPTOR, JAK2 | PIK3CB 67/4885PIK3CD 31/4885PIK3CA 13/4885 |
| US-20080132502-A1 | 5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors | MTOR, PIK3R5, PIK3CA | PIK3CB 18/4885PIK3CD 6/4885PIK3CA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.