Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 12/20 | 0.83 |
| ▸ | AKR1A1 | P14550 | 3/20 | 0.83 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311471 | 1.00 | AKR1B1 (0.83) | AKR1B1AKR1A1AKR1B10MAPT | |
| (R,S)-Fidarestat SCHEMBL29941924 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| (R,S)-Fidarestat SCHEMBL2855039 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| Fidarestat SCHEMBL48827 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| (R,S)-Fidarestat SCHEMBL1219758 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| (R,S)-Fidarestat SCHEMBL48828 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| Fidarestat SCHEMBL29546775 | 0.91 | AKR1B1 (1.00) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL8311883 | 0.89 | AKR1B1 (0.81) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9733540 | 0.87 | AKR1B1 (0.78) | AKR1B1AKR1A1AKR1B10MAPT | |
| SCHEMBL9411779 | 0.86 | AKR1B1 (0.80) | AKR1B1AKR1A1AKR1B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0193415-B1 | SPIRO-3-HETEROAZOLIDINE COMPOUNDS AND SALTS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL AGENTS THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-06-26 | — | — | EP | claimed |
| EP-0264586-B1 | HYDANTOIN DERIVATIVES FOR TREATING COMPLICATIONS OF DIABETES | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-04-03 | — | — | EP | claimed |
| EP-0264586-A1 | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-04-27 | — | — | EP | claimed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| EP-0193415-A2 | Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1986-09-03 | — | — | EP | claimed |
| JP-2218675-A | — | — | None | — | — | JP | disclosed |
| JP-2218674-A | — | — | None | — | — | JP | disclosed |
| JP-3017075-A | — | — | None | — | — | JP | disclosed |
| US-5447946-A | Inhibitors of aldose reductase | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1995-09-05 | — | — | US | disclosed |
| EP-0193415-B1 | SPIRO-3-HETEROAZOLIDINE COMPOUNDS AND SALTS THEREOF, THEIR PREPARATION AND PHARMACEUTICAL AGENTS THEREOF | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-06-26 | — | — | EP | disclosed |
| EP-0264586-B1 | HYDANTOIN DERIVATIVES FOR TREATING COMPLICATIONS OF DIABETES | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-5001240-A | Process for preparing optically active hydantoins | SANWA KAGAKU KENKYYUSHO CO., LTD. (JP) | 1991-03-19 | — | — | US | disclosed |
| US-4985574-A | CHEMICAL INTERMEDIATES, BENZOPYRAN COMPOUNDS | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |
| US-4978758-A | REACTING OPTICALLY ACTIVE 3,4-DIHYDRO-4-OXO-2H-1-BENZOPYRAN-2-CARBOXYLIC ACID DERIVATIVES WITH ALKALI METAL CYANIDE AND AMMONIUM CARBONATE, ESTERIFYING, AMIDATING | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1990-12-18 | — | — | US | disclosed |
| JP-H02218675-A | 6-FLUOROCHROMONE-2-CARBOXYLIC ACID AND PRODUCTION THEREOF | NIPPON KAYAKU CO LTD | 1990-08-31 | — | — | JP | disclosed |
| JP-H02218674-A | PRODUCTION OF 6-FLUORO-4-CHROMANONE-2-CARBOXYLIC ACID | NIPPON KAYAKU CO LTD | 1990-08-31 | — | — | JP | disclosed |
| US-4861792-A | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| EP-0264586-A1 | Hydantoin derivatives for treating complications of diabetes | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-04-27 | — | — | EP | disclosed |
| US-4740517-A | INHIBIT ALDOSE REDUCTASE | SANWA KAGAKU KENYUSHO CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| EP-0193415-A2 | Spiro-3-heteroazolidine compounds and salts thereof, their preparation and pharmaceutical agents thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1986-09-03 | — | — | EP | disclosed |