SCHEMBL9251006

SCHEMBL9251006

CC[C@H]1CC[C@H](c2ccc(CCc3ccc(F)cc3F)cc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.44
HTR2C P28335 6/20 0.44
FFAR4 Q5NUL3 2/20 0.41
NR3C2 P08235 1/20 0.39
SPHK1 Q9NYA1 3/20 0.38
IDO1 P14902 2/20 0.36
AGXT P21549 2/20 0.36
DGAT1 O75907 1/20 0.35
DAO P14920 1/20 0.35
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9251014 1.00 HTR2A (0.44) HTR2AHTR2CFFAR4NR3C2SPHK1
SCHEMBL9253086 0.88 SPHK1 (0.43) HTR2AHTR2CFFAR4SPHK1
SCHEMBL9253092 0.88 SPHK1 (0.43) HTR2AHTR2CFFAR4SPHK1
SCHEMBL9260196 0.87 SPHK1 (0.45) HTR2AHTR2CFFAR4SPHK1
SCHEMBL9260205 0.87 SPHK1 (0.45) HTR2AHTR2CFFAR4SPHK1
SCHEMBL11163592 0.86 SPHK1 (0.45) SPHK1DGAT1
SCHEMBL11163600 0.86 SPHK1 (0.45) SPHK1DGAT1
SCHEMBL10648242 0.84 FFAR4 (0.36) HTR2AHTR2CFFAR4SPHK1KCNH2
SCHEMBL10648248 0.84 FFAR4 (0.36) HTR2AHTR2CFFAR4SPHK1KCNH2
SCHEMBL9250662 0.83 SPHK1 (0.39) SPHK1DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995009829-A1 2,4-DIFLUOROBENZENES AND THEIR USE IN LIQUID CRYSTAL MIXTURES MERCK PATENT GMBH (DE) 1995-04-13 WO disclosed