Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.71 |
| ▸ | EDNRB | P24530 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947142 | 0.88 | EDNRA (0.77) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL8784559 | 0.84 | EDNRA (0.71) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL8784246 | 0.84 | EDNRA (0.71) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL8786523 | 0.83 | EDNRA (0.70) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL8785104 | 0.83 | EDNRA (1.00) | EDNRA | |
| SCHEMBL7644292 | 0.82 | EDNRA (0.72) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7946125 | 0.81 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7939667 | 0.81 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7858820 | 0.81 | EDNRA (0.79) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7849770 | 0.80 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |