Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27314267 | 0.86 | EGFR (0.51) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL3971054 | 0.85 | EGFR (0.55) | EGFRPIK3CDPIK3CAARTDO2 | |
| SCHEMBL6998128 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL9776814 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL22315252 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL2573576 | 0.81 | EGFR (0.59) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL30918007 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL3821058 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAARFGFR4 | |
| SCHEMBL6650672 | 0.80 | EGFR (0.38) | EGFRPIK3CDPIK3CAARTDO2 | |
| SCHEMBL19338494 | 0.79 | EGFR (0.51) | EGFRPIK3CDPIK3CAARFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153595-A1 | CHROMANE DERIVATIVES AS EGFR SELECTIVE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-25 | — | — | WO | disclosed |
| CN-102858754-A | RAF inhibitor compounds and methods of use thereof | ARRAY BIOPHARMA INC | 2013-01-02 | — | — | CN | disclosed |
| US-5401751-A | Enzyme inhibitors for 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| US-5283245-A | Antiinflammatory agent, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-01 | — | — | US | disclosed |
| US-5236919-A | Inhibitorsof enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-17 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5089495-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |
| EP-0381375-A1 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-08-08 | — | — | EP | disclosed |