Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | JAK1 | P23458 | 7/20 | 0.44 |
| ▸ | TYK2 | P29597 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9253585 | 0.91 | PTGER4 (0.47) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9248699 | 0.90 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PTGER4 | |
| Acetic Acid SCHEMBL9248143 | 0.85 | JAK2 (0.56) | JAK2JAK1TYK2JAK3PTGER4 | |
| Bromide SCHEMBL9248603 | 0.83 | SIRT2 (0.51) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL8863337 | 0.82 | PTGER4 (0.47) | JAK2JAK1TYK2JAK3PTGER4 | |
| Hydrochloric Acid SCHEMBL9245428 | 0.81 | PTGER4 (0.47) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9255435 | 0.81 | PTGER4 (0.52) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9252718 | 0.80 | JAK2 (0.44) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9247609 | 0.80 | HDAC6 (0.56) | JAK2JAK1TYK2JAK3PTGER4 | |
| SCHEMBL9248924 | 0.80 | PTGER4 (0.48) | JAK2JAK1TYK2JAK3PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434150-A | Anticoagulants, cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1995-07-18 | — | — | US | disclosed |
| EP-0531883-A1 | Condensed 5-membered ring heterocycles, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1993-03-17 | — | — | EP | disclosed |