Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9306122 | 0.78 | HSD17B10 (0.47) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8134231 | 0.77 | HSD17B10 (0.46) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| SCHEMBL9305128 | 0.75 | CYP2D6 (0.50) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8138785 | 0.75 | HSD17B10 (0.50) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| SCHEMBL9303584 | 0.73 | CYP2D6 (0.57) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| SCHEMBL9257071 | 0.73 | CYP11B1 (0.47) | HSD17B10KDM4ETSHRTBXAS1 | |
| SCHEMBL9257063 | 0.73 | HSD17B10 (0.40) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| SCHEMBL8141253 | 0.72 | HSD17B10 (0.45) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8135773 | 0.72 | CYP2D6 (0.56) | HSD17B10KDM4ETSHRALDH1A1LMNA | |
| SCHEMBL9304161 | 0.70 | HSD17B10 (0.40) | HSD17B10KDM4ETSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428169-A | Antidepressants, treating compulsive disorders, stuttering, trichotillomania | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | claimed |
| CN-1049658-C | Pyrazolo[4,3-c]pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST MARION ROUSSEL INC (US) | 2000-02-23 | — | — | CN | disclosed |
| US-5428169-A | Antidepressants, treating compulsive disorders, stuttering, trichotillomania | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5428169-A | Antidepressants, treating compulsive disorders, stuttering, trichotillomania | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| CN-1099033-A | Pyrazolo [4,3-c] pyridine, their preparation method and as the purposes of serotonin reuptake inhibitors | HOECHST ROUSSEL PHARMA (US) | 1995-02-22 | — | — | CN | disclosed |
| US-5380847-A | Reaction of 1-methylpiperidine-4-hydrazine, ketone and titanium isopropoxide to form hydrazone | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0594001-A1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5264576-A | Antiserotonin agents, antidepressants and obsessive-compulsive disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |