SCHEMBL9254925

SCHEMBL9254925

CCCC/C=C/C1CCC(C2CCC(CCc3ccc(F)c(F)c3)CC2)CC1

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.32
SLC6A4 P31645 1/20 0.32
SLC6A3 Q01959 1/20 0.32
CYP3A4 P08684 1/20 0.30
CYP2C8 P10632 1/20 0.30
CYP2D6 P10635 1/20 0.30
CYP2C9 P11712 1/20 0.30
CYP2C19 P33261 1/20 0.30
S1PR3 Q99500 1/20 0.30
BCHE P06276 1/20 0.30
MAOA P21397 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9254918 1.00 SLC6A2 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9482836 1.00 SLC6A2 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9482838 1.00 SLC6A2 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9480391 0.97 CYP3A4 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9480395 0.97 CYP3A4 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9480401 0.97 CYP3A4 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9480387 0.97 CYP3A4 (0.32) SLC6A2SLC6A4SLC6A3CYP3A4CYP2C8
SCHEMBL9252335 0.93 SLC6A2 (0.33) SLC6A2SLC6A4SLC6A3MAOAMAOB
SCHEMBL9252330 0.93 SLC6A2 (0.33) SLC6A2SLC6A4SLC6A3MAOAMAOB
SCHEMBL9480884 0.93 SLC6A2 (0.33) SLC6A2SLC6A4SLC6A3MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5454974-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1995-10-03 US disclosed
US-5302317-A Halobenzene liquid crystals HOFFMANN-LA ROCHE INC. (US) 1994-04-12 US disclosed
EP-0315014-B1 Halogenated benzene derivatives HOFFMANN LA ROCHE (CH) 1994-01-12 EP disclosed
EP-0315050-B1 ALCENYL BICYCLOHEXANES F. HOFFMANN-LA ROCHE AG (CH) 1993-09-01 EP disclosed
US-5230826-A HALOBENZENE LIQUID CRYSTALS HOFFMANN-LA ROCHE INC. (US) 1993-07-27 US disclosed
US-5185098-A Liquid crystalline mixtures containing 3,4-difluorophenyl-substituted bicyclohexyls HOFFMANN-LA ROCHE INC. (US) 1993-02-09 US disclosed
US-5013477-A Alkenylbicyclohexane liquid crystals HOFFMANN-LA ROCHE INC. (US) 1991-05-07 US disclosed
EP-0331933-A2 Liquid crystal mixture with a low optical anisotropy F. HOFFMANN-LA ROCHE AG (CH) 1989-09-13 EP disclosed
EP-0315050-A2 Alcenyl bicyclohexanes F. HOFFMANN-LA ROCHE AG (CH) 1989-05-10 EP disclosed