Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 10/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.54 |
| ▸ | PPARG | P37231 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349698 | 0.95 | PPARA (0.56) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL3035008 | 0.94 | PPARA (0.58) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL9172207 | 0.94 | PPARA (0.50) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL9827395 | 0.92 | CYP2D6 (0.53) | CYP2D6PPARAPPARGKCNH2DHFR | |
| SCHEMBL8927722 | 0.91 | PPARA (0.62) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL8778537 | 0.91 | PPARA (0.58) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL3021697 | 0.89 | PPARA (0.60) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL3031825 | 0.89 | PPARA (0.60) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL9579218 | 0.89 | PPARA (0.60) | CYP2D6PPARAPPARGKCNH2CNR1 | |
| SCHEMBL7854103 | 0.89 | PPARA (0.60) | CYP2D6PPARAPPARGKCNH2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5434164-A | Carbostyril derivatives and salts thereof and pharmaceutical compositions for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1995-07-18 | — | — | US | disclosed |
| EP-0240015-B1 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMA CO LTD (JP) | 1994-12-28 | — | — | EP | disclosed |
| US-5008274-A | Carbostyril derivatives and salts thereof and pharmaceutical composition for inhibiting adhesion of thrombocytes | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0240015-A2 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-07 | — | — | EP | disclosed |