Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.69 |
| ▸ | PGR | P06401 | 1/20 | 0.69 |
| ▸ | HTR2A | P28223 | 1/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13817790 | 1.00 | CYP19A1 (0.69) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| SCHEMBL6245812 | 0.83 | CYP19A1 (0.58) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| SCHEMBL11980206 | 0.82 | CYP19A1 (0.84) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| SCHEMBL6245546 | 0.82 | CYP19A1 (0.63) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| SCHEMBL8980330 | 0.82 | CYP19A1 (0.68) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| Exemestane SCHEMBL1781618 | 0.81 | CYP19A1 (1.00) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| Exemestane SCHEMBL2233503 | 0.81 | CYP19A1 (1.00) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| Exemestane SCHEMBL172893 | 0.81 | CYP19A1 (1.00) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| Exemestane SCHEMBL6215 | 0.81 | CYP19A1 (1.00) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 | |
| Exemestane SCHEMBL21698489 | 0.81 | CYP19A1 (1.00) | CYP19A1KDM4EALDH1A1ABCB11NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620823-A1 | 6,7$g(a)-DIFLUOROMETHYLENANDROSTA-1,4-DIEN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1994-10-26 | — | — | EP | claimed |
| WO-1994010190-A1 | 6,7α-DIFLUOROMETHYLENANDROSTA-1,4-DIEN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-05-11 | — | — | WO | claimed |
| EP-2556082-B1 | SUBSTITUTED ANDROST-4-ENE DIONES | UNIV EMORY (US) | 2017-02-22 | — | — | EP | disclosed |
| US-20150148321-A1 | SUBSTITUTED ANDROST-4-ENE DIONES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-28 | — | — | US | disclosed |
| US-8969327-B2 | Substituted androst-4-ene diones | EMORY UNIVERSITY (US) | 2015-03-03 | — | — | US | disclosed |
| US-20130157988-A1 | SUBSTITUTED ANDROST-4-ENE DIONES | EMORY UNIVERSITY (US) | 2013-06-20 | — | — | US | disclosed |
| EP-0656901-A1 | FLUORINATED 6-METHYLENANDROSTA-1,4-DIEN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-06-14 | — | — | EP | disclosed |
| WO-1995001366-A1 | FLUORINATED 6-METHYLENANDROSTA-1,4-DIEN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | PHARMACIA S.P.A. (IT) | 1995-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130157988-A1 | SUBSTITUTED ANDROST-4-ENE DIONES | HSD17B11, AR, NR5A1 | CYP19A1 5/4885KDM4E 2222/4885ALDH1A1 756/4885 |
| US-20150148321-A1 | SUBSTITUTED ANDROST-4-ENE DIONES | HSD17B11, AR, NR5A1 | CYP19A1 5/4885KDM4E 2222/4885ALDH1A1 756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.