Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.61 |
| ▸ | GHSR | Q92847 | 1/20 | 0.60 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9267815 | 0.92 | PSEN1 (0.57) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8817762 | 0.87 | PSEN1 (0.63) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8818255 | 0.87 | PSEN1 (0.69) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL8819517 | 0.85 | PSEN1 (0.69) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL9263280 | 0.84 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8817371 | 0.84 | PSEN1 (0.68) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL9258814 | 0.83 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8817705 | 0.83 | PSEN1 (0.69) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL9265002 | 0.83 | PSEN1 (0.69) | MEN1KMT2APSEN1PSEN2APH1B | |
| SCHEMBL6122402 | 0.82 | PSEN1 (0.66) | MEN1KMT2APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | SHIONOGI & CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135997-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A LACTAM OR BENZENESULFONAMIDE COMPOUND | BACE1, STS, APP | MEN1 4518/4885KMT2A 1883/4885PSEN1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.