⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3896194 | 0.96 | — | — | |
| SCHEMBL925414 | 0.82 | — | — | |
| SCHEMBL28807232 | 0.78 | — | — | |
| SCHEMBL8411582 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL1880943 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL6513703 | 0.75 | — | — | |
| SCHEMBL13043201 | 0.75 | — | — | |
| SCHEMBL12811978 | 0.72 | — | — | |
| SCHEMBL7290 | 0.70 | — | — | |
| Ethylene Glycol SCHEMBL7596816 | 0.70 | CYP2D6 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2540320-A1 | LEPTOMYCIN DERIVATIVES | SANOFI (FR) | 2013-01-02 | — | — | EP | disclosed |
| CN-101466409-B | Leptomycin derivatives | SANOFI AVENTIS | 2012-11-21 | — | — | CN | disclosed |
| EP-2032172-B1 | LEPTOMYCIN DERIVATIVES | SANOFI SA (FR) | 2012-06-06 | — | — | EP | disclosed |
| US-20110002947-A1 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | US | disclosed |
| US-7816543-B2 | Leptomycin derivatives | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | disclosed |
| US-20090182038-A1 | Leptomycin Derivatives | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | US | disclosed |
| CN-101466409-A | Leptomycin derivatives | SANOFI AVENTIS (FR) | 2009-06-24 | — | — | CN | disclosed |
| EP-2032172-A2 | LEPTOMYCIN DERIVATIVES | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007144709-A2 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2007-12-21 | — | — | WO | disclosed |
| EP-1864682-A1 | Leptomycin derivatives | Sanofi-Aventis (FR) | 2007-12-12 | — | — | EP | disclosed |
| US-5972630-A | DETERMINING THE PRESENCE OF AN ANALYTE IN SAMPLE; COMPLEXING TWO COMPLEMENTARY SPECIFIC BINDING MEMBERS; THE MEMBERS ARE LIGAND AND RECEPTOR IN SOLUTION, ANALYZING ENZYME ACTIVITY, EVALUATING ACTIVITY BY AMOUNT OF ANALYTE IN SAMPLE | DADE BEHRING MARBURG GMBH (DE) | 1999-10-26 | — | — | US | disclosed |
| US-5919641-A | INCUBATING SAMPLE WITH ENZYME BOUND TO FIRST SPECIFIC BINDING PAIR MEMBER AND ENZYME INHIBITOR BOUND TO SECOND SPECIFIC BINDING PAIR MEMBER, DETECTING ENZYME ACTIVITY WHEN ANALYTE BINDS TO ONE PAIR MEMBER INTERFERING WITH ORIGINAL BINDING | DADE BEHRING MARBURG GMBH (DE) | 1999-07-06 | — | — | US | disclosed |
| EP-0532187-B1 | Homogeneous immunoassays using enzyme inhibitors | BEHRINGWERKE AG (DE) | 1996-10-30 | — | — | EP | disclosed |
| EP-0375422-B1 | Composition and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine | BEHRINGWERKE AG (DE) | 1996-07-03 | — | — | EP | disclosed |
| US-5328828-A | Immunoassay for amphetamines with antibodies for conjugation and enzymes | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| EP-0532187-A1 | Homogeneous immunoassays using enzyme inhibitors | BEHRINGWERKE Aktiengesellschaft (DE) | 1993-03-17 | — | — | EP | disclosed |
| US-5135863-A | Immunoassay; drug abuse | SYNTEX (U.S.A.) INC. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0375422-A2 | Composition and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine | BEHRINGWERKE Aktiengesellschaft (DE) | 1990-06-27 | — | — | EP | disclosed |