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SCHEMBL9258136

SCHEMBL9258136

Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)CC(c4ccccc4)c4ccccc4)cccc23)c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ EDNRA P25101 5/20 0.70
▸ EDNRB P24530 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9258558 0.87 EDNRA (0.73) EDNRAEDNRB
SCHEMBL9256506 0.84 EDNRA (0.65) EDNRAEDNRB
SCHEMBL9258147 0.84 EDNRA (0.66) EDNRAEDNRB
SCHEMBL8785104 0.83 EDNRA (1.00) EDNRA
SCHEMBL9284343 0.83 EDNRA (0.73) EDNRA
SCHEMBL9259520 0.83 EDNRA (0.61) EDNRAEDNRB
SCHEMBL9256470 0.83 EDNRA (0.67) EDNRAEDNRB
SCHEMBL7951110 0.82 EDNRA (0.78) EDNRAEDNRB
SCHEMBL9261973 0.82 EDNRA (0.66) EDNRAEDNRB
SCHEMBL8785707 0.82 EDNRA (0.71) EDNRAEDNRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5378715-A Sulfonamide endothelin antagonists BRISTOL-MYERS SQUIBB CO. (US) 1995-01-03 — — US disclosed