Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.30 |
| ▸ | HTR1F | P30939 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31507834 | 0.85 | CHEK1 (0.44) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL312171 | 0.85 | CHEK1 (0.44) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL14547760 | 0.84 | ADORA1 (0.40) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL7889654 | 0.83 | ADORA1 (0.40) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL9255608 | 0.80 | MEN1 (0.38) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL9247529 | 0.78 | ADORA1 (0.36) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL13915418 | 0.74 | SMN1; SMN2 (0.47) | ADORA1MAPTF2HSD17B10L3MBTL1 | |
| SCHEMBL14547909 | 0.72 | MEN1 (0.43) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL19994265 | 0.72 | KDR (0.43) | ADORA1MEN1KMT2AMAPTF2 | |
| SCHEMBL3801893 | 0.71 | ADORA1 (0.44) | ADORA1MEN1KMT2AMAPTF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426187-A | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| EP-0576211-A2 | Process for the synthesis of 4-hydroxy-5-halopyrrolo 2,3-D pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-12-29 | — | — | EP | disclosed |
| US-5235053-A | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates | ELI LILLY AND COMPANY (US) | 1993-08-10 | — | — | US | disclosed |