Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | CLK3 | P49761 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513103 | 0.89 | IDO1 (0.63) | MKNK1PIM1LRRK2IDO1CLK2 | |
| SCHEMBL1921806 | 0.85 | MKNK1 (0.47) | MKNK1PIM1LRRK2IDO1CLK2 | |
| SCHEMBL9251358 | 0.85 | CLK2 (0.54) | MKNK1PIM1LRRK2IDO1JAK2 | |
| SCHEMBL1922328 | 0.85 | MAP2K4 (0.56) | MKNK1PIM1LRRK2IDO1CLK2 | |
| SCHEMBL1922154 | 0.85 | MAPK14 (0.51) | MKNK1LRRK2IDO1NTRK1CLK2 | |
| Hydrochloric Acid SCHEMBL9260992 | 0.84 | MKNK1 (0.46) | MKNK1PIM1LRRK2IDO1CLK2 | |
| SCHEMBL2242478 | 0.81 | LRRK2 (0.59) | MKNK1LRRK2IDO1 | |
| SCHEMBL10533662 | 0.80 | IDO1 (0.74) | MKNK1PIM1LRRK2IDO1NTRK1 | |
| SCHEMBL27817994 | 0.79 | MAPT (0.59) | MKNK1PIM1LRRK2IDO1ALDH1A1 | |
| SCHEMBL15543826 | 0.78 | PIM1 (0.52) | MKNK1PIM1LRRK2IDO1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5428169-A | Antidepressants, treating compulsive disorders, stuttering, trichotillomania | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5380847-A | Reaction of 1-methylpiperidine-4-hydrazine, ketone and titanium isopropoxide to form hydrazone | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0594001-A1 | Pyrazolo 4,3-c pyridines, a process for their preparation and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5296491-A | Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1994-03-22 | — | — | US | disclosed |
| US-5264576-A | Antiserotonin agents, antidepressants and obsessive-compulsive disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-23 | — | — | US | disclosed |