⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532483 | 0.83 | — | — | |
| SCHEMBL8835280 | 0.81 | — | — | |
| SCHEMBL8002627 | 0.74 | — | — | |
| SCHEMBL498637 | 0.69 | — | — | |
| SCHEMBL56822 | 0.67 | — | — | |
| SCHEMBL9021833 | 0.65 | — | — | |
| SCHEMBL1929747 | 0.65 | — | — | |
| SCHEMBL9021371 | 0.65 | — | — | |
| SCHEMBL142252 | 0.65 | — | — | |
| SCHEMBL8002254 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0311313-B1 | Heterocyclic spiro compounds and their preparation | YAMANOUCHI PHARMA CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5412096-A | Treatment of senile dementia, Alzheimer*s disease, cholinergic activators | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-RE34653-E | 1-oxa-8-azaspiro/4,5/decane compounds | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-07-05 | — | — | US | disclosed |
| US-5041549-A | Cholinergin agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-08-20 | — | — | US | disclosed |
| US-4996210-A | Cognition activators, nervous system disorders; muscarinic acetylcholine receptor agonists; 2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane for example | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4940795-A | Heterocyclic spiro compounds and methods for preparing the same | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1990-07-10 | — | — | US | disclosed |
| EP-0311313-A2 | Heterocyclic spiro compounds and their preparation | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1989-04-12 | — | — | EP | disclosed |