Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13260909 | 0.84 | HMGCR (0.41) | HMGCR | |
| SCHEMBL20211424 | 0.84 | TOP2A (0.45) | TOP2A | |
| SCHEMBL9287478 | 0.82 | TOP2A (0.39) | TOP2AHMGCR | |
| SCHEMBL9274773 | 0.81 | TOP2A (0.36) | TOP2A | |
| SCHEMBL9270300 | 0.81 | TOP2A (0.36) | TOP2AHMGCR | |
| SCHEMBL23992669 | 0.80 | TOP2A (0.34) | TOP2A | |
| SCHEMBL19231350 | 0.80 | TOP2A (0.34) | TOP2A | |
| SCHEMBL9274167 | 0.79 | TOP2A (0.40) | TOP2A | |
| SCHEMBL9266676 | 0.79 | TOP2A (0.40) | TOP2A | |
| SCHEMBL9343987 | 0.79 | HMGCR (0.42) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072696-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | NATIONAL SCIENCE FOUNDATION | 2018-03-15 | — | — | US | disclosed |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | CORNELL UNIVERSITY (US) | 2014-04-17 | — | — | US | disclosed |
| US-8530677-B2 | Substituted 3-hydroxy-delta-lactones from epoxides | CORNELL UNIVERSITY (US) | 2013-09-10 | — | — | US | disclosed |
| US-20100145046-A1 | Substituted 3-hydroxy-delta-lactones from epoxides | ENERGY, UNITED STATES DEPARTMENT OF | 2010-06-10 | — | — | US | disclosed |
| US-20100145046-A1 | Substituted 3-hydroxy-delta-lactones from epoxides | ENERGY, UNITED STATES DEPARTMENT OF | 2010-06-10 | — | — | US | disclosed |
| US-5443970-A | SEPARATION OF ISOMERS IN A MIXTURE BY SELECTIVE REACTION | ZENECA LIMITED (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0604483-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1994-07-06 | — | — | EP | disclosed |
| WO-1993006235-A1 | PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 4-HYDROXYTETRAHYDRO-2-PYRANONE DERIVATIVES | ZENECA LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145046-A1 | Substituted 3-hydroxy-delta-lactones from epoxides | EBP, CYP8B1, HSD3B2 | TOP2A 550/4885HMGCR 160/4885 |
| US-20180072696-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | EBP, CYP8B1, HSD3B2 | TOP2A 550/4885HMGCR 160/4885 |
| US-20140107339-A1 | SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES | EBP, CYP8B1, HSD3B2 | TOP2A 550/4885HMGCR 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.