Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9192784 | 0.87 | CYP19A1 (0.53) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9192916 | 0.83 | CYP19A1 (0.59) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9196678 | 0.83 | CYP19A1 (0.59) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9266594 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9267605 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9194268 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9192364 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9194557 | 0.82 | CYP19A1 (0.61) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| Hydrochloric Acid SCHEMBL9316765 | 0.81 | CYP19A1 (0.60) | CYP19A1CYP11B1CYP11B2TBXAS1LMNA | |
| SCHEMBL9190773 | 0.80 | CYP19A1 (0.56) | CYP19A1CYP11B1CYP11B2GPR119TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411735-B1 | Cycloalkylenazoles, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicines | SCHERING AG (DE) | 1995-05-17 | — | — | EP | claimed |
| US-5411982-A | Cycloalkylene azoles, and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-02 | — | — | US | claimed |
| US-5411982-A | Cycloalkylene azoles, and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-02 | — | — | US | disclosed |
| US-5280035-A | Cycloalkylene azoles and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5135937-A | Aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-08-04 | — | — | US | disclosed |