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SCHEMBL9265604

SCHEMBL9265604

CC(C)c1cccc(C(C)C)c1NC(=O)NC1CCC(c2ccccc2)CC1

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 1/20 0.58
▸ LMNA P02545 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ EPHX1 P07099 1/20 0.46
▸ TRPV1 Q8NER1 7/20 0.46
▸ LPAR1 Q92633 1/20 0.45
▸ ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9265827 0.85 TRPV1 (0.53) EPHX2TRPV1
SCHEMBL9273423 0.82 EPHX2 (0.61) EPHX2LMNAKMT2AEPHX1
SCHEMBL9269185 0.81 EPHX2 (0.60) EPHX2LMNAKMT2AEPHX1
SCHEMBL9271744 0.81 EPHX2 (0.60) EPHX2LMNAKMT2AEPHX1
SCHEMBL9273652 0.81 EPHX2 (0.60) EPHX2KMT2AEPHX1
SCHEMBL9272996 0.81 KMT2A (0.53) KMT2AEPHX1TRPV1
SCHEMBL9267546 0.81 EPHX2 (0.60) EPHX2KMT2AEPHX1
SCHEMBL9273953 0.81 EPHX2 (0.60) EPHX2KMT2AEPHX1
SCHEMBL9269179 0.81 EPHX2 (0.60) EPHX2LMNAKMT2AEPHX1
SCHEMBL9266884 0.80 EPHX2 (0.54) EPHX2LMNAKMT2AEPHX1LPAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5420164-A Enzyme inhibitors YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1995-05-30 — — US disclosed
EP-0507291-A1 Cyclohexylurea compounds YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1992-10-07 — — EP disclosed