Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.65 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.65 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | KDM4A | O75164 | 4/20 | 0.76 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.76 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.65 |
| ▸ | INSR | P06213 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CHAT | P28329 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9268306 | 1.00 | KDM4A (0.76) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL10845330 | 0.98 | KDM4A (0.76) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL10845327 | 0.98 | KDM4A (0.76) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Water SCHEMBL10851042 | 0.96 | KDM4A (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Water SCHEMBL10851048 | 0.96 | KDM4A (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Water SCHEMBL10851038 | 0.96 | KDM4A (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL26091666 | 0.94 | CHRM2 (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL14984278 | 0.94 | CHRM2 (0.72) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| Bromide SCHEMBL30379301 | 0.92 | CHRM2 (0.74) | KDM4AKDM2ACHRM2CHRM4CHRM5 | |
| SCHEMBL18102245 | 0.92 | CHRM2 (0.70) | KDM4AKDM2ACHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642678-A1 | OPTICALLY NON-LINEAR MATERIALS | BTG INTERNATIONAL LIMITED (GB) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993024859-A1 | OPTICALLY NON-LINEAR MATERIALS | BRITISH TECHNOLOGY GROUP LTD. (GB) | 1993-12-09 | — | — | WO | disclosed |