Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163313 | 0.82 | EGFR (0.57) | EGFRSRCNR4A2HTTMAOB | |
| SCHEMBL6588485 | 0.82 | NR4A2 (0.46) | EGFRSRCNR4A2ALDH1A1DUSP3 | |
| SCHEMBL9159861 | 0.81 | SRC (0.58) | EGFRSRCNR4A2ALDH1A1MAOB | |
| SCHEMBL9165050 | 0.81 | EGFR (0.58) | EGFRSRCNR4A2MAOBMEN1 | |
| SCHEMBL6005094 | 0.80 | MAOB (0.61) | NR4A2ALDH1A1HTTMAOBKMT2A | |
| SCHEMBL28583451 | 0.80 | CREBBP (0.56) | EGFRSRCALDH1A1DUSP3HTT | |
| SCHEMBL9159816 | 0.78 | SRC (0.60) | SRCNR4A2MAOBRAB9AGPR27 | |
| SCHEMBL9165527 | 0.77 | SRC (0.61) | EGFRSRCNR4A2ALDH1A1HTT | |
| SCHEMBL9158566 | 0.77 | EGFR (0.61) | EGFRSRCNR4A2ALDH1A1MAOB | |
| SCHEMBL7384494 | 0.76 | SLC6A4 (0.47) | EGFRSRCNR4A2ALDH1A1DUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |