Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | HMGCR | P04035 | 6/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272006 | 1.00 | NR4A2 (0.47) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL6949668 | 0.91 | NR4A2 (0.45) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL8953313 | 0.85 | HMGCR (0.49) | HMGCR | |
| SCHEMBL8953297 | 0.85 | HMGCR (0.49) | HMGCR | |
| SCHEMBL10474682 | 0.84 | HMGCR (0.42) | NR4A2PDE4DNR1I2HMGCRTBXA2R | |
| SCHEMBL27308983 | 0.82 | HMGCR (0.52) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL8949666 | 0.82 | HMGCR (0.44) | NR4A2PDE4DNR1I2HMGCRRXRA | |
| SCHEMBL10410206 | 0.81 | HMGCR (0.44) | PDE4DNR1I2HMGCRTBXA2RADRA1A | |
| SCHEMBL9264631 | 0.81 | HMGCR (0.46) | NR4A2PDE4DNR1I2HMGCRTBXA2R | |
| SCHEMBL10410205 | 0.81 | HMGCR (0.44) | PDE4DNR1I2HMGCRTBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401746-A | FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND HMG-COA REDUCTASE | BAYER AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5169857-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-08 | — | — | US | disclosed |
| US-5006530-A | Certain 7-[2,6-diisopropyl-4-phenyl-5-lower alkoxymethyl-pyrid-3-yl]-3,5-dihydroxy-6-enoates and derivatives useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-09 | — | — | US | disclosed |