Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.64 |
| ▸ | EDNRB | P24530 | 7/20 | 0.60 |
| ▸ | DHPS | P49366 | 2/20 | 0.59 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.59 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.59 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428350 | 0.91 | EDNRA (0.53) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7429594 | 0.91 | EDNRA (0.53) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7819735 | 0.90 | EDNRA (0.49) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL14367998 | 0.87 | EDNRA (0.67) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL3667813 | 0.85 | EDNRA (0.47) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7329858 | 0.84 | EDNRA (0.62) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL11929105 | 0.84 | EDNRA (0.70) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL1723226 | 0.84 | EDNRA (0.61) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL11925214 | 0.82 | EDNRA (0.68) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL13281278 | 0.78 | EDNRA (1.00) | EDNRAEDNRBDHPSABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012073135-A1 | AN IMPROVED PROCESS FOR PREPARING BOSENTAN | ALEMBIC PHARMACEUTICALS LIMITED (IN) | 2012-06-07 | — | — | WO | disclosed |