Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9103136 | 0.89 | HPGD (0.47) | NPC1HPGD | |
| SCHEMBL9103144 | 0.89 | HPGD (0.47) | NPC1HPGD | |
| SCHEMBL9106200 | 0.89 | HPGD (0.47) | NPC1HPGD | |
| SCHEMBL9104397 | 0.88 | HPGD (0.48) | NPC1HPGD | |
| SCHEMBL9102981 | 0.80 | CHRNA1 (0.47) | HRH3TACR2 | |
| SCHEMBL9102990 | 0.80 | CHRNA1 (0.47) | HRH3TACR2 | |
| SCHEMBL31478927 | 0.80 | CHRNA1 (0.47) | HRH3TACR2 | |
| SCHEMBL9103805 | 0.79 | KCNH2 (0.39) | HRH3TACR2 | |
| SCHEMBL9103811 | 0.79 | KCNH2 (0.39) | HRH3TACR2 | |
| SCHEMBL9102303 | 0.77 | HPGD (0.57) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |