SCHEMBL9280702

SCHEMBL9280702

CCCc1ccc(-c2ccc(-c3ccc(OC(F)F)cc3)c(F)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 4/20 0.41
S1PR1 P21453 2/20 0.39
S1PR3 Q99500 2/20 0.39
RARA P10276 2/20 0.39
DAO P14920 1/20 0.39
RARG P13631 1/20 0.39
DRD1 P21728 1/20 0.38
PPARA Q07869 3/20 0.38
PPARG P37231 2/20 0.38
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
ACACB O00763 1/20 0.36
ACACA Q13085 1/20 0.36
CNR2 P34972 1/20 0.36
PTGER4 P35408 1/20 0.36
MCL1 Q07820 1/20 0.36
MAOB P27338 1/20 0.36
FFAR4 Q5NUL3 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9226888 1.00 RARB (0.41) RARBS1PR1S1PR3RARADAO
SCHEMBL9223754 0.93 RARB (0.40) RARBS1PR1S1PR3DAODRD1
SCHEMBL9221144 0.93 RARB (0.45) RARBS1PR1S1PR3PPARAPPARG
SCHEMBL9229221 0.92 RARB (0.48) RARBS1PR1S1PR3RARADAO
SCHEMBL9234145 0.92 RARB (0.48) RARBS1PR1S1PR3RARADAO
SCHEMBL8990910 0.92 RARB (0.41) RARBS1PR1S1PR3DAODRD1
SCHEMBL9227552 0.91 RARB (0.53) RARBS1PR1S1PR3RARARARG
SCHEMBL9227591 0.91 RARB (0.53) RARBS1PR1S1PR3RARARARG
SCHEMBL6059249 0.91 AKR1C3 (0.38) RARBS1PR1S1PR3DAOPPARA
SCHEMBL9228145 0.90 RARB (0.55) RARBS1PR1S1PR3RARARARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0413785-B1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK PATENT GMBH (DE) 1995-12-20 EP disclosed
EP-0413785-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS. MERCK PATENT GMBH (DE) 1991-02-27 EP disclosed
WO-1990009420-A1 LIQUID CRYSTALLINE MEDIA CONTAINING FLUORINATED OLIGOPHENYLS MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-08-23 WO disclosed