Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.80 |
| ▸ | TTK | P33981 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562220 | 0.92 | LRRK2 (0.81) | LRRK2CYP1A2TTK | |
| SCHEMBL4534843 | 0.91 | LRRK2 (0.77) | LRRK2CYP1A2TTK | |
| SCHEMBL4562024 | 0.89 | LRRK2 (0.77) | LRRK2CYP1A2TTK | |
| SCHEMBL9969926 | 0.89 | LRRK2 (1.00) | LRRK2CYP1A2TTK | |
| SCHEMBL4561677 | 0.87 | LRRK2 (0.83) | LRRK2CYP1A2TTK | |
| SCHEMBL4561158 | 0.87 | LRRK2 (0.80) | LRRK2CYP1A2TTK | |
| SCHEMBL5021473 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL21613974 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL18453966 | 0.85 | LRRK2 (0.81) | LRRK2CYP1A2TTK | |
| SCHEMBL4561723 | 0.84 | LRRK2 (0.66) | LRRK2CYP1A2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646819-A1 | ASSAYS AND BIOMARKERS FOR LRRK2 | Genentech, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012075046-A9 | ASSAYS AND BIOMARKERS FOR LRRK2 | GENENTECH, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012075046-A1 | ASSAYS AND BIOMARKERS FOR LRRK2 | GENENTECH, INC. (US) | 2012-06-07 | — | — | WO | disclosed |