Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12616689 | 0.81 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL28277542 | 0.80 | S1PR5 (0.44) | SMN1; SMN2ALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL28278967 | 0.80 | S1PR5 (0.44) | SMN1; SMN2ALDH1A1S1PR4S1PR1S1PR3 | |
| SCHEMBL11155986 | 0.80 | NEK2 (0.36) | SMN1; SMN2NEK2ALDH1A1LMNARORC | |
| SCHEMBL23467070 | 0.80 | MAPT (0.50) | SMN1; SMN2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL10566816 | 0.79 | ATM (0.36) | SMN1; SMN2NEK2ALDH1A1LMNARORC | |
| SCHEMBL1119544 | 0.77 | NEK2 (0.35) | SMN1; SMN2NEK2ALDH1A1LMNARORC | |
| SCHEMBL20300584 | 0.76 | TP53 (0.39) | SMN1; SMN2NEK2ALDH1A1LMNARORC | |
| SCHEMBL460719 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2NEK2ALDH1A1S1PR4S1PR1 | |
| SCHEMBL30226530 | 0.76 | SMN1; SMN2 (0.35) | SMN1; SMN2NEK2ALDH1A1LMNARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461050-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-24 | — | — | US | disclosed |
| EP-0326526-A1 | Aminoketones of substituted dibenzo- and pyridobenzo-azepinones and pharmaceutical compositions | ISTITUTO DE ANGELI S.p.A. (IT) | 1989-08-02 | — | — | EP | disclosed |