Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 3/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278081 | 0.95 | PIK3CD (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9274132 | 0.94 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9275659 | 0.90 | PIK3CD (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL9288017 | 0.89 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9286773 | 0.88 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9281091 | 0.87 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9286368 | 0.86 | PIK3CD (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9278074 | 0.84 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9279553 | 0.83 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL9284829 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643319-A1 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012074869-A1 | BENZOXAZEPINES AS INHIBITORS OF PI3K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-06-07 | — | — | WO | disclosed |