Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9908471 | 0.82 | CTSC (0.65) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL28122659 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL11187709 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL601566 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL31026629 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL3008134 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL601567 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL28122660 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL21808154 | 0.82 | CTSC (0.68) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL9776976 | 0.81 | CTSC (0.67) | CTSCCYP3A4CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644892-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1995-03-29 | — | — | EP | disclosed |