Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27690047 | 0.88 | AURKA (0.40) | AURKAPARP1FEN1CAMKK2MAPT | |
| SCHEMBL1939685 | 0.83 | MAP2K1 (0.42) | AURKAPARP1FEN1MAPTKMT2A | |
| SCHEMBL21819026 | 0.80 | AURKA (0.45) | AURKAPARP1FEN1CAMKK2MAPT | |
| SCHEMBL16497523 | 0.78 | AURKA (0.46) | AURKAPARP1FEN1CAMKK2MAPT | |
| SCHEMBL14533462 | 0.77 | AURKA (0.44) | AURKAPARP1FEN1MAPTKMT2A | |
| SCHEMBL29856130 | 0.77 | SMN1; SMN2 (0.50) | MAPTKMT2AMEN1HTTALDH1A1 | |
| SCHEMBL16497245 | 0.75 | MAP2K1 (0.51) | AURKAPARP1FEN1CAMKK2MAPT | |
| SCHEMBL1940624 | 0.74 | EGFR (0.45) | AURKAPARP1FEN1MAPTKMT2A | |
| SCHEMBL6964299 | 0.74 | KDM4E (0.57) | MAPTKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL30602834 | 0.74 | KDM4E (0.57) | MAPTKMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712408-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | Dompé S.P.A. (IT) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004742-A1 | TROPYL 7-AZAINDOL-3-YLCARBOXYAMIDES AS ANTITUSSIVE AGENT | DOMPE'SPA (IT) | 1995-02-16 | — | — | WO | disclosed |