Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8763697 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAKDM4EHPGDMEN1 | |
| SCHEMBL8763694 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAKDM4EHPGDMEN1 | |
| SCHEMBL10645286 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAKDM4EHPGDMEN1 | |
| SCHEMBL23942214 | 0.76 | MCL1 (0.48) | SMN1; SMN2LMNAKDM4EHPGDMEN1 | |
| SCHEMBL30327641 | 0.75 | EPHX1 (0.58) | MEN1KMT2AEPHX1ZDHHC20ZDHHC2 | |
| SCHEMBL7550275 | 0.75 | EPHX1 (0.48) | SMN1; SMN2LMNAHPGDMEN1TP53 | |
| SCHEMBL3257790 | 0.74 | EPHX1 (0.68) | MEN1KMT2AEPHX1ZDHHC20ZDHHC2 | |
| SCHEMBL7548924 | 0.74 | EPHX1 (0.52) | SMN1; SMN2LMNAHPGDMEN1TP53 | |
| SCHEMBL7550565 | 0.74 | EPHX1 (0.52) | SMN1; SMN2LMNAHPGDMEN1TP53 | |
| SCHEMBL7546089 | 0.74 | EPHX1 (0.52) | SMN1; SMN2LMNAHPGDMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0652214-A1 | N-Aryl-2-cyano-3-hydroxy propenamide derivatives, a method for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1995-05-10 | — | — | EP | disclosed |