Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 10/20 | 0.60 |
| ▸ | PTGES | O14684 | 3/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23270813 | 0.92 | PTGES2 (0.62) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL30181343 | 0.92 | PTGES2 (0.62) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL30770982 | 0.91 | PTGES2 (0.58) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL23270776 | 0.91 | PTGES2 (0.58) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL25968363 | 0.89 | PTGES2 (0.64) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL30181561 | 0.87 | PTGES2 (0.64) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL23270837 | 0.87 | PTGES2 (0.64) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL25970457 | 0.85 | PTGES2 (0.51) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL23270793 | 0.84 | PTGES2 (0.73) | PTGES2PTGESPTGS1PTGS2ALOX5AP | |
| SCHEMBL30181215 | 0.84 | PTGES2 (0.73) | PTGES2PTGESPTGS1PTGS2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419049-B1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC (CA) | 1995-04-12 | — | — | EP | disclosed |
| US-5380850-A | Quinoline hydrazine intermediates | MERCK FROSST CANADA, INC. (CA) | 1995-01-10 | — | — | US | disclosed |
| WO-1994013293-A2 | (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5272145-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-12-21 | — | — | US | disclosed |
| US-5204344-A | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA, INC. (CA) | 1993-04-20 | — | — | US | disclosed |
| EP-0419049-A1 | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes | MERCK FROSST CANADA INC. (CA) | 1991-03-27 | — | — | EP | disclosed |