Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8513875 | 1.00 | PIK3CA (0.33) | PIK3CAPRKDCCD274CREBBPMTOR | |
| SCHEMBL9283608 | 0.92 | PIK3CA (0.34) | PIK3CAPRKDCCD274MTOR | |
| SCHEMBL9286881 | 0.92 | PIK3CA (0.34) | PIK3CAPRKDCCD274MTOR | |
| SCHEMBL9286805 | 0.92 | PIK3CA (0.31) | PIK3CAPRKDCMTOR | |
| SCHEMBL9286808 | 0.92 | PIK3CA (0.31) | PIK3CAPRKDCMTOR | |
| SCHEMBL9288187 | 0.91 | PIK3CA (0.32) | PIK3CAPRKDCCREBBPMTOR | |
| SCHEMBL9286771 | 0.91 | PIK3CA (0.32) | PIK3CAPRKDCCREBBPMTOR | |
| SCHEMBL8538028 | 0.90 | PIK3CA (0.33) | PIK3CAPRKDCMTOR | |
| SCHEMBL8611745 | 0.90 | PIK3CA (0.33) | PIK3CAPRKDCMTOR | |
| SCHEMBL15408221 | 0.90 | PIK3CA (0.33) | PIK3CAPRKDCCREBBPMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140018347-A1 | BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2014-01-16 | — | — | US | claimed |
| US-20140018347-A1 | BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2014-01-16 | — | — | US | disclosed |
| WO-2012071511-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018347-A1 | BENZOXAZEPINES AS INHIBITORS OF mTOR AND METHODS OF THEIR USE AND MANUFACTURE | MTOR, RICTOR, RPTOR | PIK3CA 135/4885PRKDC 4070/4885CD274 3868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.