SCHEMBL9290369

SCHEMBL9290369

COc1ccc(N2C(=O)c3cccc4c(-c5ccccc5)ccc2c34)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.53
MEN1 O00255 2/20 0.53
PDE6D O43924 1/20 0.52
NR1H3 Q13133 3/20 0.49
PGR P06401 1/20 0.46
USP2 O75604 2/20 0.44
ALDH1A1 P00352 6/20 0.44
KDM4E B2RXH2 5/20 0.44
MAPT P10636 2/20 0.44
HTT P42858 1/20 0.44
KEAP1 Q14145 1/20 0.44
NFE2L2 Q16236 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GAA P10253 2/20 0.44
SCN2A Q99250 1/20 0.43
ESR1 P03372 1/20 0.43
CASP3 P42574 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290465 0.95 KMT2A (0.50) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290476 0.95 KMT2A (0.55) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL12561356 0.91 KMT2A (0.51) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290422 0.90 KMT2A (0.49) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290345 0.90 KMT2A (0.49) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290450 0.90 KMT2A (0.47) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290385 0.87 PDE6D (0.58) KMT2AMEN1PDE6DUSP2ALDH1A1
SCHEMBL9290435 0.87 KMT2A (0.48) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290419 0.87 KMT2A (0.48) KMT2AMEN1PDE6DNR1H3PGR
SCHEMBL9290430 0.85 GRM5 (0.47) KMT2AMEN1PDE6DNR1H3USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 KMT2A 4130/4885MEN1 3537/4885PDE6D 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.