SCHEMBL9291387

SCHEMBL9291387

Cc1cc(C([S])c2ccccc2)cc(C(C)(C)C)c1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.47
CYP2C19 P33261 3/20 0.47
CYP1A2 P05177 2/20 0.47
TSHR P16473 2/20 0.44
CYP3A4 P08684 1/20 0.44
GABRA1 P14867 1/20 0.43
GABRB2 P47870 1/20 0.43
CA2 P00918 3/20 0.39
ALDH1A1 P00352 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
POLB P06746 1/20 0.39
TYR P14679 1/20 0.39
CACNA1A O00555 1/20 0.38
CACNA2D1 P54289 1/20 0.38
CACNB1 Q02641 1/20 0.38
SIRT1 Q96EB6 1/20 0.37
MEN1 O00255 1/20 0.36
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8772429 0.84 CYP1A2 (0.50) CYP2C9CYP2C19CYP1A2TSHRCYP3A4
SCHEMBL30343456 0.76 CYP2C9 (0.61) CYP2C9CYP2C19CYP1A2TSHRGABRA1
SCHEMBL1597804 0.76 CYP2C9 (0.61) CYP2C9CYP2C19CYP1A2TSHRGABRA1
SCHEMBL1597972 0.75 CYP1A2 (0.55) CYP2C9CYP2C19CYP1A2TSHRCYP3A4
SCHEMBL1151101 0.74 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2TSHRGABRA1
SCHEMBL30467047 0.74 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2TSHRGABRA1
SCHEMBL5446120 0.74 CYP1A2 (0.59) CYP2C9CYP2C19CYP1A2TSHRCYP3A4
SCHEMBL4450533 0.74 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2TSHRGABRA1
SCHEMBL9133639 0.73 TSHR (0.49) CYP2C9CYP2C19CYP1A2TSHRCYP3A4
SCHEMBL11327008 0.73 CYP2C9 (0.53) CYP2C9CYP2C19CYP1A2TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5352719-A Blended with synthetic or natural polymers ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-10-04 US disclosed
US-5319090-A Benzotriazole and oxanilide UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-06-07 US disclosed
US-5233047-A Benzotriazole UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-08-03 US disclosed
US-5116976-A HINDERED AMINE LIGHT STABILIZER HYDRAZIDES ATOCHEM NORTH AMERICA, INC (US) 1992-05-26 US disclosed
EP-0467344-A1 Hindered amine light stabilizer hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-01-22 EP disclosed
EP-0409840-A4 BENZOTRIAZOLE AND OXANILIDE UV ABSORBER HYDRAZIDES 1991-09-04 EP disclosed
US-5041545-A 2-hydroxybenzophenone hydrazides and derivatives thereof ATOCHEM NORTH AMERICA, INC. (US) 1991-08-20 US disclosed
EP-0409840-A1 BENZOTRIAZOLE AND OXANILIDE UV ABSORBER HYDRAZIDES ELF ATOCHEM NORTH AMERICA, INC. (US) 1991-01-30 EP disclosed
US-4980420-A Benzotriazole and oxanilide UV absorber hydrazides ATOCHEM NORTH AMERICA, INC. (US) 1990-12-25 US disclosed
WO-1990009369-A1 BENZOTRIAZOLE AND OXANILIDE UV ABSORBER HYDRAZIDES ATOCHEM NORTH AMERICA, INC. (US) 1990-08-23 WO disclosed