Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 6/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8136239 | 0.95 | MEN1 (0.52) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL9293699 | 0.90 | CACNA1F (0.61) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL9292952 | 0.90 | MEN1 (0.51) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8130762 | 0.87 | MEN1 (0.61) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8120568 | 0.86 | MEN1 (0.52) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8120142 | 0.85 | POLB (0.62) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8135200 | 0.85 | POLB (0.62) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL9292834 | 0.85 | POLB (0.62) | MEN1KMT2AKCNH2POLBCACNA1F | |
| Hydrochloric Acid SCHEMBL9598387 | 0.85 | CACNA1F (0.58) | MEN1KMT2AKCNH2POLBCACNA1F | |
| SCHEMBL8102400 | 0.84 | MEN1 (0.61) | MEN1KMT2AKCNH2POLBCACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342846-A | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents | SYNPHAR LABORATORIES, INC. (CA) | 1994-08-30 | — | — | US | disclosed |