Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9294394 | 1.00 | TACR1 (0.86) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294391 | 1.00 | TACR1 (0.86) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL6554784 | 0.95 | TACR1 (0.81) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL6554776 | 0.95 | TACR1 (0.81) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL6554765 | 0.95 | TACR1 (0.81) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294797 | 0.94 | TACR1 (0.80) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294028 | 0.94 | TACR1 (0.76) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294024 | 0.94 | TACR1 (0.76) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294792 | 0.94 | TACR1 (0.80) | TACR1CYP2D6KCNH2HTR1AHTR2A | |
| SCHEMBL9294015 | 0.94 | TACR1 (0.76) | TACR1CYP2D6KCNH2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |