Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 18/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9294462 | 1.00 | TACR1 (0.56) | TACR1KDM1ACYP2D6 | |
| SCHEMBL9294460 | 1.00 | TACR1 (0.56) | TACR1KDM1ACYP2D6 | |
| SCHEMBL9034624 | 0.92 | TACR1 (0.64) | TACR1CYP2D6 | |
| SCHEMBL5555958 | 0.92 | TACR1 (0.64) | TACR1CYP2D6 | |
| SCHEMBL9294678 | 0.92 | TACR1 (0.64) | TACR1CYP2D6 | |
| SCHEMBL9034619 | 0.92 | TACR1 (0.64) | TACR1CYP2D6 | |
| SCHEMBL9294139 | 0.92 | TACR1 (0.64) | TACR1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9287664 | 0.90 | TACR1 (0.63) | TACR1CYP2D6 | |
| SCHEMBL4939417 | 0.83 | KDM1A (0.54) | TACR1KDM1ACYP2D6 | |
| SCHEMBL4939411 | 0.83 | KDM1A (0.54) | TACR1KDM1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436334-B1 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5332817-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1994-07-26 | — | — | US | disclosed |
| US-5232929-A | 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use | PFIZER INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1991009844-A1 | SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436334-A2 | 3-Aminopiperidine derivatives and related nitrogen containing heterocycles | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |